Where the Niners end up by season's end will hinge even more on the ongoing development of their newbies.

The 49ers, at 4-2 on the season, are still atop the NFC West based on their 3-0 record within the division.

San Francisco didn't just lose Sunday. They also lost arguably their best remaining defender in Fred Warner, the All-Pro linebacker at the heart of Robert Saleh's unit.

Fred Warner’s first-quarter ankle injury has devastating implications for the rest of the season, and it certainly crushed the 49ers’ morale during and after the game.

The San Francisco 49ers have already been depleted by injuries this season, and a key member of the defense appeared to suffer a serious injury on Sunday.

Egbuka has been an immediate force and was the first player in NFL history with 25 catches, 400 yards (he entered Sunday with 445) and five touchdowns in his first five career games.

Injuries have ravaged the San Francisco 49ers across their first six games with numerous standout players impacted, and wide receiver Jauan Jennings was among those to miss time. He returned to action Sunday in the loss to the Tampa Bay Buccaneers after a pair of absences and after the game revealed that he is playing through a number of ailments.

With the dealing with several injuries to their pass-catchers for the Week 6 game against the , it was assumed that Jauan Jennings would have a big game.