Buccaneers, San Francisco 49ers and NFL
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Find single game tickets to the Tampa Bay Buccaneers vs. San Francisco 49ers NFL Week 6 matchup on Sunday, October 12, 2025 at Raymond James Stadium.
Connor Colby has been the 49ers' biggest issue in pass protection, but he has been passable as a run blocker. Now, he gets the Buccaneers defense, which is the best in the NFL at defending the run.
Two dangerous quarterbacks are on the San Francisco 49ers' schedule this season, according to comments from Kyle Shanahan, who did not hesitate to state that both signal-callers are currently performing at MVP levels.