Before leading the San Francisco 49ers to an overtime win over the Los Angeles Rams on Thursday night, Mac Jones made a terrifying discovery at the team's hotel. According to Dianna Russini of The Athletic,

A road loss to the Rams on Thursday night would not have been surprising, but the San Francisco 49ers instead turned in their best game of the season in a 26-23 overtime victory.

Our 49ers vs. Rams predictions believe Matthew Stafford and the potent Los Angeles pass attack will pull away from San Francisco on Thursday, October 2, 2025. Free NFL picks for Week 5.

Broadcast and streaming information for the San Francisco 49ers Week 5 matchup against the Los Angeles Rams at

The 49ers defeated the Rams 26-23 in overtime behind a terrific performance from Mac Jones, another workmanlike effort from Christian McCaffrey, a career night from Kendrick Bourne and several clutch red zone plays from their defense.

Rams blew a winnable game in OT against 49ers. Critical mistakes at key moments turned Stafford's 389-yard night into a bitter loss.

In his first full game as a 49er against the Rams, McCaffrey had a rushing touchdown, a receiving touchdown and even threw a touchdown pass.

The San Francisco 49ers announced several roster updates ahead of the Thursday Night Football game against the Los Angeles Rams. Promoted to the active roster from the practice squad: QB Adrian Martinez Martinez joins the active roster after the 49ers ruled out starting...

The Tampa Bay Buccaneers will be playing a big game against the San Francisco 49ers, but neither team will be at full strength. And unfortunately for the 49ers,

Get the best bets, predictions, props & odds for Week 5's Thursday Night Football matchup between the 49ers and Rams on Thursday, October 2.

Mac Jones will have additional motivation as he leads the San Francisco 49ers against the Tampa Bay Buccaneers.