The Indianapolis Colts try to keep their share of the AFC South lead while the Arizona Cardinals try to halt a losing streak: Stats, scores.

The Arizona Cardinals face the Indianapolis Colts, led by quarterback Daniel Jones, on Sunday, Oct. 12, 2025 at Lucas Oil Stadium in Indianapolis.

But the reality is that the 4-1 Indianapolis Colts are a team to watch in the fall of 2025. They are coming off a dominant 40-6 win over the Las Vegas Raiders. Their only loss this season came from the Los Angeles Rams, who defeated them 27-20 in Week 4. Aside from that one hiccup, everything has been going Indy's way.

Jacoby Brissett, filling in for an injured Kyler Murray, finished 27-for-44 for 320 yards and two touchdowns with one interception.

The NFC West takes center stage when two teams battling it out for second place in the division play. Follow along with our live blog.

Demercado, Murray, Michael Carter and Bam Knight combined to rush for 168 yards. That's a good sign for the Cardinals considering veteran James Conner (foot) is out for the season and backup Trey Benson (knee) will miss at least three more games.

The Arizona Cardinals (2-3) led the Tennessee Titans 21-6 at halftime before being outscored 16-0 in the second half.