The Arizona Cardinals' remaining strength of schedule for 2025 is among the NFL's toughest with matchups against the top six passing offenses.

The Cardinals are projected by ESPN to have the tenth overall pick in the 2026 NFL Draft. The season is far from over, and there's plenty of football left to be played - though it's clear the Cardinals will need to right the ship sooner rather than later in order to salvage the season.

Jacoby Brissett, filling in for an injured Kyler Murray, finished 27-for-44 for 320 yards and two touchdowns with one interception.

Those absences can be added to a list of injuries that already includes the Cardinals' top two running backs (James Conner and Trey Benson), first-round pick Walter Nolen, edge rusher B.J. Ojulari and slot corner Garrett Williams.

Arizona Cardinals linebacker Mack Wilson Sr. (2) watches as Indianapolis Colts running back Jonathan Taylor (28) scores a touchdown during a game on Sunday, Oct. 12, 2025, at Lucas Oil Stadium in Indianapolis. The Colts defeated the Cardinals 31-27. / Christine Tannous/IndyStar / USA TODAY NETWORK via Imagn Images

Entering the season with the 27th easiest strength of schedule, many experts had the Arizona Cardinals as a favorite to make they’re first playoff push since 2021.

The moment you start to believe you have a handle on a college football season, the very next Saturday tends to blow up a few storylines.