Off the rails is about the best way to describe the ending of the Arizona Cardinals' 22-21 loss to the Tennessee Titans in Week 5.

The Arizona Cardinals again failed to seal the deal when it mattered in their Week 6 loss to the Indianapolis Colts, a game where the offense finally came alive but the defense had its worst outing of the season. Now, the Cardinals are losers of their last four games - all by a combined nine points.

Learn which TV channel or how to live stream the NFL Week 6 Indianapolis Colts and Arizona Cardinals game, Sunday, Oct. 12.

There are several players to start and sit in fantasy football from the Tennessee Titans' and Arizona Cardinals' Week 5 matchup.

This article was originally published on www.si.com/nfl/cardinals as Ranking 5 Most Important Players in Cardinals vs Colts .

There are times things get a little more complicated — and difficult — than expected. Like when the Indianapolis Colts lost Anthony Richardson Sr. in pre-game warm-ups Sunday at Lucas Oil Stadium. The backup quarterback fractured an orbital bone in an eye when he was working with a resistance band.