Learn which TV channel or how to live stream the NFL Week 6 Indianapolis Colts and Arizona Cardinals game, Sunday, Oct. 12.

The Indianapolis Colts rally in the fourth quarter to defeat the Arizona Cardinals. Here are the winners and losers from the NFL Week 6 matchup.

Arizona Cardinals linebacker Mack Wilson Sr. (2) watches as Indianapolis Colts running back Jonathan Taylor (28) scores a touchdown during a game on Sunday, Oct. 12, 2025, at Lucas Oil Stadium in Indianapolis. The Colts defeated the Cardinals 31-27. / Christine Tannous/IndyStar / USA TODAY NETWORK via Imagn Images

But it has been a while since the Cardinals faced the Colts. They last played in 2021 on Christmas Day. To get ready for the game, Colts Wire managing editor Paul Bretl helps preview the matchup, taking us "behind enemy lines," telling us about the players to watch, giving us fantasy advice and more!

Thursday Night Football's Arizona Cardinals vs Seattle Seahawks NFL Week 4 game on Sept. 25, 2025, will feature the Cardinals' new Rivalries uniform.

Oct 12, 2025; Indianapolis, Indiana, USA; Indianapolis Colts tight end Tyler Warren (84) celebrates with running back Jonathan Taylor (28) after a reception against the Arizona Cardinals during the first quarter of the game at Lucas Oil Stadium. Mandatory Credit: Trevor Ruszkowski-Imagn Images / Trevor Ruszkowski-Imagn Images