Detroit's defense has been solid in recent weeks, and will be the key for defeating the Bengals and their talented array of playmakers. By putting pressure on Jake Browning, the Lions can neutralize the impact of Ja'Marr Chase and Tee Higgins.

The Lions hit the road with a chance to extend their winning streak to four straight against a struggling Bengals team.

Detroit is a 10.5-point favorite in the latest Lions vs. Bengals odds from SportsLine consensus, while the over/under for total points scored is 49.5. The Lions are -599 money line favorites (risk $599 to win $100),

Sep 14, 2025; Cincinnati, Ohio, USA; Cincinnati Bengals defensive end Trey Hendrickson (91) celebrates his sack during the fourth quarter against the Jacksonville Jaguars at Paycor Stadium. Mandatory Credit: Joseph Maiorana-Imagn Images / Joseph Maiorana-Imagn Images

Browning’s miscues gave the Detroit Lions excellent field position, and they capitalized, defeating the Cincinnati Bengals 37-24 in Week 5 at Paycor Stadium.

Even in a deflating loss, Ja’Marr Chase reminded everyone why he’s among the NFL’s elite. The star receiver hauled in six receptions for 101 yards and two touchdowns in a game that Cincinnati definitely needed big plays on offense. Chase continues to be the offense’s heartbeat — even on a day when much else went wrong.

The Cincinnati Bengals plan to assess their situation following a humbling loss to the Detroit Lions. Changes could soon follow.

At the end of a blowout that few fans were still watching on Sunday, an obscure aspect of the NFL's kickoff rules led to a highly unusual situation.

Detroit Lions are taking on the Cincinnati Bengals in a Week 5 NFL matchup on Sunday in Cincinnati. Here's our scouting report and game prediction.

As a result, the Bengals had no choice but to seek out an alternative option to play under center. Bengals head coach Zac Taylor expressed to reporters postgame he felt the offens