You can also see the model's best bets for every Week 6 NFL game, including Cowboys vs. Panthers, Seahawks vs. Jaguars and Chiefs vs. Lions. Finally, SportsLine expert RJ White, who is 57-35 (+2470) over his last 92 NFL picks, has locked in multiple Week 6 NFL picks. Visit SportsLine to see his best bets.

Week 6 in the 2025 NFL season features some fantastic matchups on Sunday, culminating with a marquee matchup between the Detroit Lions and Kansas City Chiefs on

Sunday's matchup between the Tampa Bay Buccaneers and San Francisco 49ers brought us more than Bucs wideout Tez Johnson's highlight-reel-worthy, <a href=" 45-yard touchdown and a heroic <a href=" scramble by Baker Mayfield.

He has recorded a touchdown reception in four of five games and has had at least 100 yards receiving in two consecutive games

You can also see the model's best bets for every Week 5 NFL game, including Commanders vs. Chargers, Patriots vs. Bills and Titans vs. Cardinals. Finally, SportsLine expert RJ White, who is 42-29 (+1490) over his last 71 NFL picks, has locked in multiple Week 5 NFL picks. Visit SportsLine to see his best bets.

Photo highlights from the sixth week of the NFL season. This gallery was curated by AP photo editors. ___ AP sports: AP photography:

How do you see this one playing out? The Saints hope to build on the momentum from their first win, but a white-hot Patriots team won't make it easy:

The Saints are seeking their second consecutive victory after beating the New York Giants 26-14 in New Orleans a week ago. The Saints enter the game with a record of 1-4 while the Patriots are 3-2 following a 23-20 victory over the Buffalo Bills.