Critically ill sepsis patients did not fare better with prolonged infusions of meropenem compared with intermittent infusions of the beta-lactam antibiotic, a randomized trial showed. Among over 600 ...

Please provide your email address to receive an email when new articles are posted on . When comparing continuous vs. intermittent infusions, the absolute difference in 90-day mortality was ...

Please provide your email address to receive an email when new articles are posted on . De-escalation of beta-lactam antibiotics was associated with a decreased risk of new resistance among patients ...

Prolonged infusion of beta-lactam antibiotics for sepsis or septic shock tended to improve mortality compared with conventional intermittent infusion in the BLING III trial, and a meta-analysis ...

For patients admitted to non–intensive care unit (ICU) wards who have suspected community-acquired pneumonia (CAP), a strategy of empirical treatment with a beta-lactam antibiotic alone was found to ...

Researchers have simplified the operation of an important class of chemical transformation: synthesis of beta-lactams, the intricate scaffold of many antibiotics. Their experimental protocol minimizes ...

This presentation explores the pharmacokinetics (PK) and pharmacodynamics (PD) of β-lactam antibiotic dosing, particularly in ICU patients. To optimize PK/PD targets, two strategies are possible and ...