Despite injuries they have suffered to rob them of star power, the 49ers have managed to go 4-1 following their tried and true formula under coach Kyle Shanahan, but this time with a different quarter...

The San Francisco 49ers (4-1) visit the Tampa Bay Buccaneers (4-1) at Raymond James Stadium on Sunday, October 12, 2025, and best bets information is available.

Winning the spread, total and Baker Mayfield over 244.5 passing yards parlay for the Buccaneers-49ers game pays out an estimated $55.35 on a $10 bet using the computer picks below.