Business Wire

1910 Genetics Launches CANDID-CNS™, an AI Model for Blood-Brain Barrier Permeability Prediction that Outperforms the Industry Standard

- CANDID-CNS TM achieves an 83% success rate for predicting small molecule brain penetration and distribution versus a 64% success rate for the industry standard CNS-MPO score - Only ~2% of small ...
Morningstar

1910 Publishes CANDID-CNS™, an AI Model That Unlocks Beyond Rule of 5 Chemical Space and Stereochemistry to Predict Blood–Brain Barrier Penetration

CANDID-CNS™ is the new state-of-the-art AI model for BBB penetration: it achieves 87% AUPRC on bRo5 small molecules compared to 56% by Pfizer’s CNS MPO. CANDID-CNS™ distinguishes CNS penetrant ...
News Medical

Understanding the evolution of CNS drug models from microdialysis to PBPK

This episode of the Pharmaron DMPK Insights Podcast Series sees Scott Summerfield (Senior Director and Head of Pharmaceutical Metabolism at Pharmaron) and Professor Elizabeth de Lange Professor in ...
Business Wire

bit.bio Launches ioAstrocytes, Advancing How Scientists Can Model the Human Brain

For the first time, scientists can now leverage the reproducibility of ioCells to study how the four major CNS cell types interact and contribute to neurological diseases. This enables more precise ...
Drexel University

A Next Generation Human Induced Pluripotent Stem Cell-derived CNS Model for the Study of Tauopathy

The emergence of human induced pluripotent stem cell (hiPSC) technology has led to the development of several useful 3D in vitro modelling platforms for the study of tauopathy. However, most of these ...
BioWorld

Insilicotrials brings mechanistic CNS models to collaboration with Axoltis on NX-210c

Insilicotrials Technologies SpA has entered into a collaborative partnership with Axoltis Pharma SA in the field of central nervous system (CNS) diseases, with the aim of optimizing the clinical ...