From memory formation to disease prevention, scientists are uncovering how chromatin structure, enzyme evolution, and epigenetic regulators orchestrate gene activity. Recent breakthroughs reveal how ...

The Theoretical Basis of Transcriptional Therapy of Cancer: Can It Be Put Into Practice? Epigenetic regulation of gene expression is mediated through alterations in the DNA methylation status, ...

Alzheimer’s disease (AD) is a neurodegenerative condition in which amyloid plaques and neurofibrillary tangles accumulate in the brain. In addition to genetic factors, DNA damage and epigenetic ...

Epigenome remodeling, including widespread changes to DNA methylation and 3D chromatin structure, is increasingly recognized as an important mechanism of gene deregulation in cancer. For example, at ...

Neurons have variable levels of chromatin compaction, shown as different shades of red. The less compact a neuron, the more likely it is to be recruited into the memory trace (green). When we form a ...

Cancer drugs are designed to shut tumors down. But sometimes, in the very act of attacking a tumor, treatment can also help a small fraction of cancer cells become harder to kill. A new study from ...

Epigenetics confers a survival advantage in plants to endure harsh weather by inducing bud dormancy. Environmental factors or intrinsic signals trigger the transition between growth and dormancy.

A new study helps explain why a promising class of cancer drugs has often failed to meet expectations in clinical trials.

A macrophage that has already fought off one infection does not return to a blank slate. It carries chemical scars, etched ...