Nature

Variation near complement factor I is associated with risk of advanced AMD

A case–control association study for advanced age-related macular degeneration was conducted to explore several regions of interest identified by linkage. This analysis identified a single nucleotide ...
Nature

Support for the involvement of complement factor I in age-related macular degeneration

After correction for multiple testing, our results were of marginal significance and so of somewhat unclear relevance to AMD when appraised in isolation. However, in light of results published by ...
Healio

GT005 gene therapy shows ability to modulate complement pathway in geographic atrophy

Please provide your email address to receive an email when new articles are posted on . In a first-in-human phase 1/2 study, GT005, an AAV2-based one-time investigational gene therapy, showed ...
EurekAlert!

Children’s Hospital of Philadelphia, Clinic for Special Children discover ultra rare form of neuroinflammatory disease is much more common in Old Order Amish than general ...

Philadelphia and Gordonville, PA, August 12, 2025 – Researchers from Children’s Hospital of Philadelphia (CHOP) and the Clinic for Special Children found that complement factor I (CFI) deficiency, an ...
Medical Xpress

Research reveals rare form of neuroinflammatory disease is more common in Old Order Amish than general population

Researchers from Children's Hospital of Philadelphia (CHOP) and the Clinic for Special Children found that complement factor I (CFI) deficiency, an ultra-rare genetic disorder that can cause ...
Business Wire

Gemini Therapeutics Announces FDA Fast Track Designation Granted for GEM103 for the Treatment of Dry Age-Related Macular Degeneration (AMD) in Patients With Complement Factor H ...

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Gemini Therapeutics, a clinical stage precision medicine company developing innovative treatments for genetically defined age-related macular degeneration (AMD), ...