Murray didn't play Sunday in Indianapolis, and backup Jacoby Brissett had a good game stepping in during the Colts' 31-27 win over the Cardinals. Brissett completed 27 of 44 pass attempts for 320 yards, two touchdowns and an interception.

How was Sunday's performance from the Cardinals' offense different under QB Jacoby Brissett? Let's look into the numbers:

Quarterback controversies are mostly fan and media creations. Coaches seldom acknowledge their existence — they can divide the locker room — which explains Jonathan Gannon’s comments after the Indianapolis loss. The Arizona head coach praised Brissett’s poise, command and experience.

The Arizona Cardinals are expected to be without Kyler Murray in Week 6, multiple outlets reported on Saturday night, Oct. 11.

The Arizona Cardinals' next game is Sunday in Week 6 against the Indianapolis Colts. Kickoff from Lucas Oil Stadium is at 1 p.m. ET (10 a.m. Arizona time). The Cardinals are 2-3 and have lost their last three games,

Jacoby Brissett, filling in for the injured Kyler Murray, balled out in Week 6, giving the Cardinals their best offensive performance of the season as 2025 had been full of struggles with Murray under center.

The season isn’t in crisis, but the next four games will say a lot about whether the 2025 Packers are worthy of competing for a Super Bowl.