Mahomes threw for 257 yards and three touchdowns, two of which went to Hollywood Brown, while adding another score on the ground. Jared Goff threw two touchdowns, one to Sam LaPorta and one to Jameson Williams, in the loss.

Baker Mayfield tossed two touchdowns to help lead the Tampa Bay Buccaneers over the San Francisco in a battle of one loss teams from Raymond James Stadium.

Live NFL updates from Tottenham Hotspur Stadium as the winless New York Jets face the Denver Broncos; watch the San Francisco 49ers against the Tampa Bay Buccaneers live on Sky Sports NFL from 6pm before the Kansas City Chiefs versus the Detroit Lions in Sunday Night Football.

Trevor Lawrence, Travis Hunter and the Jacksonville Jaguars face the Seattle Seahawks in NFL Week 6. Follow for scores, live updates and analysis.

Also, let's not ignore the tremendous season that Sam Darnold is putting together for the Seahawks. Remarkably, his completion percentage and passer rating are even better than what he produced last season with the Vikings. I think he leads Seattle into Duval County and leaves with an outright win.

It’s Week 8 of the SC high school football season and we’re tracking live SCHSL and SCISA scores from the Rock Hill area and statewide

NFL Week 6 is here and we asked USA TODAY Sports' staff for their top bets for the entire NFL slate. Here are their picks and predictions.

NFL Week 6 betting spreads, lines, point totals for every game on the NFL Week 6 schedule, with odds for favorites and underdogs in each NFL matchup.