The 49ers (4-1) travel across the country to face the Bucs (4-1), and both teams are coming off entertaining 3-point wins on the road. The 49ers — despite being riddled with injuries on offense — won Thursday night over the Rams as huge underdogs. Mac Jones filled in again for quarterback Brock Purdy and the 49ers offense looked good.

Jacksonville Jaguars (4-1) have to be considered one of the surprises in the NFL in 2025. Tied atop the AFC South with another of the league's feel-good stories, the Indianapolis Colts, Liam Coen has the Jags beginning to believe in themselves as they prepare to line up against the Seattle Seahawks (3-2) Sunday afternoon.