After diving into all 15 games on the NFL Week 6 schedule, Cohen likes the Buccaneers (-3.5, 46.5) to win and cover at home against the 49ers at 4:25 p.m. ET on Sunday, even as the Bucs deal with a lengthy injury list that includes running back Bucky Irving (foot/shoulder), receiver Chris Godwin (fibula) and receiver Mike Evans (hamstring) all out.

Monday Night Football features two NFL games today in Week 6. Who plays Monday Night Football tonight? MNF TV schedule, teams, start time, and how to watch.

Some of the site's predictions differ from NFL Week 6 odds and other NFL Week 6 picks for NFL Week 6 games. How correct will the analytics be this week? Click on each game for more NFL Week 6 predictions for that NFL matchup. All times MST. The site allows for the possibility of ties, so the numbers add up to just less than 100%.

If we had to sum up the 2025 NFL season in one word, it would be "parity." There are no more undefeated teams as we exit Week 5, and just one winless team. (Sorry, New York Jets fans.) This past week featured six double-digit comebacks,