Analogs of the pancreatic peptide hormone amylin are making strides in obesity as developers zoom in on oral drugs that can emulate or even improve on injectable GLP-1 agonists while avoiding muscle ...

Reconstruction of nerve bundles in a rhesus monkey brain. Fang Xu et al. present a method to image a whole monkey brain at micrometer resolution in 100 hours. See Xu et al. Image: Chao-Yu Yang and ...

Nguyen et al. developed a lyophilized synthetic biology circuit embedded in fabric that transmits viral detection signals through a textile-integrated waveguide. See Nguyen et al. Image: Peter Q.

An illustration of lipid nanoparticles (green circles) targeting the lung, designed using neural networks. Witten et al. present a method (LiON) using neural networks for lipid discovery and ...

Optimizing guide RNA design for Cas13. With data from massively parallel screens, Wessels et al. develop computational models to identify optimal guide RNAs for the RNA-targeting CRISPR enzyme Cas13d.

Artist’s impression of a protein translocating through a nanopore. Yu et al. identify conditions that allow complete proteins to translocate through a nanopore when driven by an electroosmotic effect.

A series of bright fluorescent RNAs enable imaging of RNA in live cells. This original image shows heterogeneity of protein translation in a cancer cell line, where mCherry protein (red) and its ...

Scanning electron micrograph of a heart-forming organoid showing a myocardial layer (pink) separated by a thin endocardial layer (blue) from an anterior foregut endoderm and vascular layer (cinnamon); ...

Staircase inspired by a DNA spiral in the BC Cancer Agency Research Centre (Vancouver, BC, Canada). This issue brings together articles focused on DNA sequencing ...

Natural and engineered Cas12 and TnpB variants offer diverse applications in genome editing and diagnostics.

Zhenan Bao and colleagues design and fabricate multilayered electronics that adapt to growing nerves, allowing chronic electrical stimulation during the fastest growth period in rats. The approach ...

Single-cell proteomics maps protein dynamics in the developing human brain.