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High-dose rifampin — 35 mg/kg daily — administered for 8 weeks showed no reduction in mortality rate compared with standard-dose rifampin — 10 mg/kg daily — in patients with tuberculous meningitis but ...

Findings from a Johns Hopkins Children's Center study in animal models show that a U.S. Food and Drug Administration (FDA)-approved antibiotic regimen for multidrug-resistant (MDR) tuberculosis (TB) ...

Tuberculosis (TB) infects about 11 million people globally each year and causes 1.4 million deaths. The most severe complication—tuberculous meningitis—occurs when TB bacteria reach the brain.

Tuberculosis (TB) is a bacterial infection of the lungs. Tuberculous meningitis (TBM) is a potential complication of TB in which the bacteria that cause TB infect the brain and spinal cord. TBM causes ...

Treatments for TB meningitis are long and can take up to 12 months. Shorter regimens can lead to better compliance, lower costs, and better outcomes for patients, adds senior author Sanjay Jain, M.D., ...

A Johns Hopkins Children's Center-led study in animals suggests that high doses of a widely used antibiotic called rifampin may safely treat and reduce the duration of treatment for the deadliest form ...

A trial of a new drug regimen to treat tuberculous meningitis (TBM) has started enrolling adults and adolescents in several countries where tuberculosis (TB) is prevalent. The Improved Management with ...

Researchers at the Francis Crick Institute have shown how the bacteria causing tuberculosis (TB) directly cross the brain's protective barrier, causing meningitis, a very severe form of the disease ...

Tuberculous Meningitis (TBM) is the most severe form of extrapulmonary tuberculosis, posing a critical global health challenge. This devastating central ...