Combined Intraperitoneal and Intravenous Chemotherapy for Women With Optimally Debulked Ovarian Cancer: Results From an Intergroup Phase II Trial Purpose: To evaluate in vivo whether the expression of ...
We report the first use of human telomerase reverse transcriptase (hTERT) expression in experimental xenotransplantation. Previously, we showed that bovine adrenocortical cells can be transplanted ...
Researchers have reported that the telomerase reverse transcriptase gene promoter was altered in 69 percent of 54 cases of bladder cancer. Telomerase reverse transcriptase alterations frequently ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, No. 41 (Oct. 12, 2004), pp. 14713-14718 (6 pages) Telomerase synthesizes telomeric DNA by copying a short ...
New research shows a transcriptase that helps time cell death varies in expression, and is unusually localized, in cancer cells. The transcriptase, Telomerase Reverse Transcriptase (TERT), is ...
Crossbow Therapeutics Inc. has provided details on the preclinical characterization for the telomerase reverse transcriptase (TERT)-targeting T-cell engager CBX-663.
A structural model of the telomerase enzyme shows how the binding domain (purple) tethers one end of the RNA component of the enzyme. (Image credit: Jansson et al., ) Researchers at UC Santa Cruz have ...
IN A MAJOR ADVANCE toward understanding a key biomolecule, scientists have solved the structure of the catalytic subunit of telomerase, the enzyme that maintains the length and integrity of telomeres, ...
The enzyme telomerase, which restores chromosome ends shortened by cell division, was discovered over three decades ago, but no view of the human enzyme at atomic resolution, approximately 3 Å, has ...
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