After diving into all 15 games on the NFL Week 6 schedule, Cohen likes the Buccaneers (-3.5, 46.5) to win and cover at home against the 49ers at 4:25 p.m. ET on Sunday, even as the Bucs deal with a lengthy injury list that includes running back Bucky Irving (foot/shoulder), receiver Chris Godwin (fibula) and receiver Mike Evans (hamstring) all out.

The remaining 1972 Miami Dolphins can pop the champagne after the last two remaining unbeaten teams, Philadelphia and Buffalo, lost as home

NFL Week 6 is here, so let's look at the odds and make some picks and predictions for the next weekend of the 2025 regular season.

Better known as 'Prop Bet Guy,' Kralstein specializes in NFL props, and he enters Week 5 on a 27-15 run on NFL player props that has returned more than $1,000 for $100 bettors. One of his top prop picks this week is going Over 13.5 total receiving yards for Houston Texans running back Woody Marks (-114).

Some of the site's predictions differ from NFL Week 6 odds and other NFL Week 6 picks for NFL Week 6 games. How correct will the analytics be this week? Click on each game for more NFL Week 6 predictions for that NFL matchup. All times MST. The site allows for the possibility of ties, so the numbers add up to just less than 100%.

The Miami Dolphins play the Los Angeles Chargers in Week 6 of the 2025 NFL season. Who wins? See our predictions and picks, plus odds for the game.

NFL Week 6 picks, predictions for every NFL game this week, including Rams-Ravens, 49ers-Buccaneers, Bengals-Packers, Lions-Chiefs, Bills-Falcons.

Who are the top NFL DFS picks for Bills vs. Falcons and Bears vs. Commanders, and which daily Fantasy sleepers should you target to differentiate your NFL DFS lineups and NFL DFS stacks? Before making any NFL DFS picks for Monday Night Football on sites like DraftKings and FanDuel,