Learn more about eLife assessments Mosquito-borne virus transmission is increasing globally. Due to a lack of effective vaccines or targeted treatments, mitigation relies on reducing human exposure to ...

The oceans buffer against climate change via biogeochemical cycles underpinned by microbial metabolic activities. While planetary-scale surveys provide baseline microbiome data, inferring metabolic ...

The manuscript presents a compelling application of the microfluidic mother machine as a "selection" machine. While individual elements of the work have existed for many years across various research ...

Plasma cell-free RNA (cfRNA) is a promising source of non-invasive biomarkers, but its clinical translation is hindered by technical challenges and a lack of protocol standardization, which ...

Although prenatal alcohol exposure (PAE) has been proposed as an early-life risk factor for Alzheimer’s disease and related dementias (AD/ADRD), the mechanistic underpinnings are underexplored.

Automated Behavioural Response (ABR) systems, which combine camera traps with automated sound playbacks, offer a solution but have been primarily used on large terrestrial mammals. Here, we ...

To assess the effect of merging computational models of evolutionary optimization and gradient descent, we developed a new algorithmic process, dubbed evolutionary conditioning (EC). EC is ...

An in vivo small-molecule drug screen in developing zebrafish larvae identifies dozens of unique chemical modulators capable of reducing atherogenic apolipoprotein B levels.

An intriguing set of electrophysiological and analytical results suggests that adult rat neurons in the medulla oblongata crucial for mediating descending pain modulation are embedded in a network ...

The findings documented here are interesting and valuable with respect to revealing genetic players that may underlie AD. However, there are concerns related to the analysis pipeline and the basic ...

This important study identifies and characterizes a set of amino acid states that can rescue protein function in the presence of substantially deleterious mutations. Some of these super-compensatory ...

Overall, these in vitro experiments demonstrate that pharmacological activation of TRPML1 stimulates AMPK via a Ca 2+ -CaMKKβ-dependent pathway, thereby promoting GLUT4 translocation to the PM. This ...