Baker Mayfield tossed two touchdowns to help lead the Tampa Bay Buccaneers over the San Francisco in a battle of one loss teams from Raymond James Stadium.

Broadcast and streaming information for the San Francisco 49ers Week 5 matchup against the Los Angeles Rams at

The San Francisco 49ers will face the Tampa Bay Buccaneers in Week 6 of the NFL season on Sunday at Raymond James Stadium.

The 49ers pulled off one of the shocking upsets of the early NFL season, ignoring multiple injuries for a 26-23 overtime victory over the Rams.

Our 49ers vs. Rams predictions believe Matthew Stafford and the potent Los Angeles pass attack will pull away from San Francisco on Thursday, October 2, 2025. Free NFL picks for Week 5.

Week 6 of the NFL season has already begun, as we saw the New York Giants, behind quarterback Jaxson Dart and running back Cam Skattebo, beat the Philadelphia Eagles 34-17 as underdogs. To kick off Sunday's schedule,

The 49ers return to Levi's Stadium this Sunday looking to stay perfect on the season, but it won't be easy. After a gritty 16-15 win over the division rival Arizona Cardinals in Week 3, San Francisco sits at 3-0, but that narrow victory came at a major cost.

Monday Night Football tonight has the Buffalo Bills traveling to the Atlanta Falcons in NFL Week 6. MNF start time, NFL schedules and how to watch.