The Commanders have won two of the three most recent meetings, including last year's victory on a 52-yard, final-play touchdown pass.
With Brock Purdy likely out, 49ers quarterback Mac Jones was limited in practice on Thursday leaving Adrian Martinez taking first-team reps.
Lakers star LeBron James will be sidelined 3-4 weeks because of sciatica on his right side, the team announced Thursday.
The New England Patriots have a chance to win for the fourth time in five games when they visit the New Orleans Saints in Week 6.
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