The insulin signaling pathway is one of the central metabolic pathways that has been shown to influence lifespan in many animal models and is probably also important for healthy aging in humans. "We ...

Adrenomedullin, a hormone first identified in an adrenal medullary tumor, disrupts the effect of insulin on the endothelium of blood vessels, leading to insulin resistance linked to obesity and type 2 ...

Insulin resistance is concomitant with type 2 diabetes, obesity, hypertension, and other features of the metabolic syndrome. Because insulin resistance is associated with cardiovascular disease, both ...

Obesity has become a global epidemic affecting diverse populations and leading to metabolic syndrome across different sexes and age groups. A significant aspect of obesity is the development of leptin ...

Scientists discover how the Fas-p53 pathway sabotages energy metabolism, offering new hope for tackling obesity and improving insulin sensitivity. Brief Communication: Expression of p53 in human ...

McGill University researchers have identified a brain function that helps explain why childhood stress raises metabolic health risks for some women later in life. A new study found that variations in ...

Insulin is a glucose-lowering hormone that targets the peripheral tissues, especially the skeletal muscle and fatty tissues. Insulin also circulates throughout the brain, wherein it can impact the ...