Genetic deficiency of otoferlin, a protein critical to synaptic transmission by the sensory hair cells of the ear, causes congenital deafness. Medicines to treat the condition are lacking; ...

Sotatercept, an activin-signaling inhibitor, reduces morbidity and mortality among patients with long-standing pulmonary ...

In the face of Israel’s ongoing assault on Gaza’s health system and the catastrophic famine caused by the devastation, U.S. physicians have an ethical obligation to respond and support immediate ...

Lawmakers and regulators have grown alarmed about vertical integration and the role of “middlemen” in the U.S. health care system. Yet pharmaceutical wholesalers have largely evaded public scrutiny.

The Corporatization of U.S. Health Care: Insight into Corporate Governance — What Motivates Hospitals and Delivery Systems. S. Lipstein . The Risks of Pharmaceutical Tariffs for ...

This feature about a student with strep throat and an unconfirmed penicillin allergy offers a case vignette accompanied by two essays, one supporting use of a nonpenicillin antibiotic and the other ...

Having worked at seven hospitals in Gaza since December 2023, an American surgeon finds value in doing whatever is possible to serve a community — and bearing witness to unimaginable human suffering.

The “One Big Beautiful Bill Act” will dramatically increase U.S. greenhouse-gas emissions, along with all their known adverse health consequences.

Cardiac glycosides are among the oldest medications in cardiovascular care, prized for their actions as positive inotropic agents and modulators of atrioventricular conduction. In heart failure with ...

The NEJM Weekly CME Program offers one AMA PRA Category 1 Credit™ for each successfully completed Weekly CME or Interactive Medical Case activity. A personal subscription to NEJM provides free access ...

Steven Lipstein is the former chief executive officer of BJC HealthCare. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal.

In a patient with treatment-resistant ulcerative colitis, CD19 CAR T-cell therapy led to drug-free remission and mucosal healing, suggesting that B-cell targeting may offer a novel therapeutic ...