The 49ers vs. Buccaneers game kicks off at 4:25 p.m. ET/1:25 p.m. PT on Sunday, Oct. 12, 2025. The Week 6 game between the 49ers and the Buccaneers will air in select markets on CBS, which means it'll also stream live in those markets on Paramount+. You can also tune in on mobile devices with NFL+.

The Tampa Bay Buccaneers will be playing a big game against the San Francisco 49ers, but neither team will be at full strength. And unfortunately for the 49ers,

In an early-season battle for NFC supremacy, the Buccaneers welcome the defending Super Bowl champions to town, as the undefeated Eagles arrive with a roster loaded with talent at every position

Our early Buccaneers vs. Seahawks predictions expect plenty of scoring at Lumen Field, with Seattle winning comfortably.

Here are three bold predictions for the Tampa Bay Buccaneers' Week 6 clash with the San Francisco 49ers for NFC supremacy.

Egbuka is doubtful to return to Sunday's game against the 49ers due to a hamstring injury, Brianna Dix of the Buccaneers' official site reports. Prior to the Buccaneers making this announcement in the third quarter,

Trevor Lawrence, Travis Hunter and the Jacksonville Jaguars face the Seattle Seahawks in NFL Week 6. Follow for scores, live updates and analysis.