Inter Miami faces a packed schedule following their Concacaf Champions Cup victory. Their MLS season begins against New York City FC, followed by the second leg against Sporting Kansas City.

Inter Miami broke records in MLS last season, and now must continue with a new, inexperienced coach and a new GM with Messi's backing.

Mascherano’s fingerprints are on the 2025 roster, as he brought in 25-year-old Argentine winger Tadeo Allende, on loan from Celta Vigo, 23-year-old Argentine defender Gonzalo Luján from San Lorenzo, 21-year-old Venezuelan midfielder Telasco Segovia, 22-year-old Argentine goalkeeper Rocco Rios Novo and 27-year-old Uruguayan center back Maxi Falcon.