Computational models of the glucoregulatory system constitute a powerful tool for preclinical evaluation and mechanistic insight into therapeutics. However, in the case of diabetes, there is a dearth ...

Au nanoclusters (NCs), with discrete electronic structures and tunable properties, are promising building blocks for nanoelectronics. However, maximizing their potential requires a deeper ...

Major challenges remain to precisely detect low-abundance proteins rapidly and cost-effectively from diverse biofluids. Here, we present a gold nanoparticle (AuNP)-supported, rapid electronic ...

l-Serine, a nonessential amino acid in humans, possesses significant physiological functions and is widely used in the food, cosmetic, and pharmaceutical industries. Driven by steadily growing market ...

The potential toxicities of chemicals to humans and wildlife remain largely unknown. In vitro bioassays have increasingly been applied for the toxicity testing of chemicals. However, most of these ...

The high clinical failure rate of small-molecule drugs is inarguably attributable to the lack of reliable predictions of chemical structure–efficacy–toxicity relationships that are applicable to ...

Noncanonical nucleic acid conformations like G-quadruplexes and i-motifs are key regulators of gene function, genome stability, and drug action. Their structural dynamics in extreme conditions of high ...

Understanding the correlation between interdot spacing and their interactions is crucial for controlling the properties of quantum dot superlattices. In this study, the interdot spacing of the ...

The molecular-level identification of diseases is recognized as a crucial aspect of precision medicine, playing an important role in the early diagnosis and surveillance of various diseases. Digital ...

Functional group conversion is a cornerstone of modern synthetic chemistry. Many strategies routinely employed for small-molecule transformations are unsuitable for modifying biomacromolecules, ...

Low loose bulk density, a characteristic commonly observed in large accumulations of needle-like crystals, has caused numerous issues in both production processes and daily life. Antisolvent ...

Metal-ammine (NH3) and metal-amide (NH2) species are common intermediates in ammonia oxidation, typically designed with weak N–H bonds to facilitate the sequential breakage of N–H bonds. Since the ...