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Are you potentially underdosing levetiracetam for seizure prophylaxis in neurocritical care patients? It's a common practice to dose levetiracetam at 500 mg q12h, but studies suggest this might not be optimal. - A prospective study of sTBI and SAH patients found that a loading dose of 20 mg/kg followed by 1000 mg q12h for 7 days resulted in fewer drug-related side effects compared to phenytoin, with no difference in early seizure incidence. This is why databases like UpToDate Lexidrug recommend
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