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Tremfya vs Ustekinumab: Tremfya is IL-23 selective, while ustekinumab blocks both IL-12 & IL-23. • Tremfya has shown superior endoscopic outcomes in some Crohn’s trials compared with ustekinumab. • Tremfya is one of the newest FDA- and EMA-approved biologics for both UC and CD (2024–2025). | MRCP UK
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