SUMO modifies GβL and mediates mTOR signaling » Department of Neurology » College of Medicine » University of Florida
SUMO modifies GβL and mediates mTOR signaling » Department of …
Apr 16, 2024
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Insulin is a highly anabolic hormone in skeletal muscle, where it activates the PI3K/Akt/mTOR pathway to stimulate protein synthesis, enhance amino acid uptake, and inhibit proteolysis for net hypertrophy. It further suppresses muscle protein breakdown while promoting translation initiation through mTORC1 signaling. In bone tissue, insulin directly binds to receptors on osteoblasts, driving their proliferation, differentiation, and collagen production via MAPK and PI3K pathways. Overall, this le
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mTOR (mechanistic Target Of Rapamycin) senses nutrients and decides whether your cells should grow or repair. High nutrients → mTOR up → Growth mode Low nutrients → mTOR down → Maintenance mode Here's why it matters: The maintenance state (low mTOR) is associated with slower aging. Animals with reduced mTOR activity tend to live longer and remain healthier. What affects mTOR: Fasting/caloric restriction (lowers it) Protein intake (raises it) Exercise (raises it acutely) Rapamycin (inhibits it) Y
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