Japp–Klingemann reaction - Alchetron, the free social encyclopedia
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Aug 18, 2017
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14.6: Reaction Mechanisms
14.6: Reaction Mechanisms
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The Beckmann rearrangement enables the conversion of oximes into amides or lactams via acid-promoted rearrangement with substituent migration. Developed by Ernst Otto Beckmann in the late 19th century, the reaction proceeds through activation of the oxime, rearrangement to a nitrilium intermediate, and subsequent attack of water to yield the amide. Learn. Review. Repeat.
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