Nicotiana glauca (tree tobacco) is interesting because it doesn’t primarily contain nicotine like N. tabacum, but anabasine, a related alkaloid. Chemically similar, but biologically distinct — anabasine acts on nicotinic acetylcholine receptors and is more toxic, especially to mammals. Historically it was studied as an insecticide and even as a pharmacological probe, but it’s not safe for casual or traditional use.Fun chemistry footnote: anabasine helped early researchers understand how “nicotin
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