Diphenhydramine (Benadryl) can cause several side effects that are unpleasant. Some people can have worsened restless legs syndrome but we do not fully understand why. This is much less likely to occur with newer antihistamines. General educational purposes only #medications #sideeffects #allergies #doctor | Zachary Rubin, MD

2.9M views · 14K reactions | Benadryl has a lot of side effects and there are better options! Make sure you are following @rubin_allergy, as he is an allergy expert and agrees, Benadryl is not “fire” #allergy #medication #doctor #sleep #emergency @thatsleepdoc Disclaimer: For educational and entertainment purposes only and should not be regarded as medical advice or replace the advice of your physician | Dr.Beachgem10 | Facebook

Benadryl Side Effects on Brain Health and Dementia Risk First-generation antihistamines like diphenhydramine (Benadryl) block histamine but also strongly block acetylcholine, a neurotransmitter essential for attention and memory. That anticholinergic effect explains many of the cognitive risks. 🧠 Memory problems and slower thinking Diphenhydramine crosses the blood–brain barrier and impairs attention, working memory, and reaction time. Controlled studies show worse vigilance and cognitive perfo